After a tight opening set where the duos could not be separated, Verbeek and Siniakova rapidly took a 5-1 lead in the tie-break.
Two brilliant rallies offered Salisbury and Stefani a glimmer of hope but the damage had already been done, and Stefani’s volley dropped long to hand Verbeek and Siniakova the opener.
A break of serve apiece in the second set teed up another tie-break, and Siniakova showed why she is a 10-time major doubles champion with clever net play and confident volleys.
The 29-year-old’s overhead smash sealed victory for the pair and Verbeek picked up his partner and hugged her before leading the crowd in singing ‘happy birthday’ to his father.
It is a maiden major title for Verbeek and a first Grand Slam mixed doubles triumph for Siniakova.
Salisbury has won the French and US Opens in the mixed alongside American Desirae Krawczyk and US and Australian titles in the men’s alongside American Rajeev Ram.