Djokovic, bidding for record 25th Grand Slam title, lost to Sinner in the French Open last four earlier this year.
The two have also met twice before at Wimbledon – in the quarter-finals in 2022 and the semi-finals in 2023, with Djokovic winning on both occasions.
However, three-time Grand Slam champion Sinner has won their past four meetings.
“Me and Novak, we know each other better because we have played quite a lot,” Sinner said.
“I’ve never won against him here in Wimbledon so it’s going to be a very, very tough challenge.”
Sinner also said he decided to play in new shoes for his match with Shelton to reduce the chances of slipping again.
“I played with completely new shoes to have more grip,” he added.
“I haven’t even played practice [in them]. It was completely new, which usually on other surfaces I don’t do.
“On grass the main priority is to have lots of grip so I have to get used to it.”
