When England last toured Argentina in 2017, Tom Curry and Sam Underhill took advantage of James Haskell, Maro Itoje and Billy Vunipola’s absences, either through Lions duty or injury, to make their debuts.
By 2019, Curry and Underhill were England’s first-choice flankers on a run to the Rugby World Cup final.
England have 10 uncapped players in their 36-strong squad for the matches in South America and a fixture against the United States in Washington DC on 19 July.
Borthwick says the step up to Test level in front of fervent Argentine fans will help identify those who can similarly kick on at international level.
“I am looking forward to seeing these players perform in that kind of atmosphere, in those kind of cauldrons,” he added.
“Lots of players can play well at club level, but then it is the players who can be Test-match animals – able to perform in the biggest arenas on the most intense stages.”